"Girls in the Hood" is Megan Thee Stallion's first release since recruiting Beyoncé for a "Savage" remix back in April.
The new track also includes a melody sample of N.W.A.'s "Boyz-N-The-Hood", originally rapped by the late Eazy-E.
The Houston rapper is yet to follow up her March EP SUGA.
Megan Thee Stallion's "Girls in the Hood" single is out now.